NGS targeted panel analysis made ingeniously simple
The varvis® software enables you to identify rare and causative CNV, SNV and Indels in a single validated process and to replace conventional ligation-based screening method with one comprehensive approach. Automate your NGS workflow and reduce your turnaround time to minutes!
A clinical decision support system – made for use in diagnostic procedures
Onboarding, IT and support services included
Validated CNV analysis for clinical diagnostics
Our automated and clinically validated CNV analysis is completely integrated into the NGS workflow. In parallel to SNVs and Indels, copy number variants are detected automatically by our bioinformatics pipeline. Performance validation with your own data is provided as a service, so you can be sure to use the varvis® software as an effective and reliable screening tool in clinical routine.
Trust your results
The quality of the CNV data is proven to be compliant with all relevant standards regarding NGS validation.
Reduce your turn-around time
For most patients the result of the CNV analysis is immediately available without an additional confirmation.
One for all
Our CNV analysis is available for all genes and insensitive to SNPs.
Supreme expert support
Our team provides first-class support regarding workflow optimization, technical issues, training and documentation – even for the tricky cases. We are here to help!
Our CNV detection algorithm was validated using thousands of clinical samples. In this example, more than 400 consecutive samples from routine diagnostics were analyzed with our bioinformatics CNV pipeline and the results were compared to gold-standard PCR-based methods to confirm the results for every single probe/target region. The numbers represent typical results that are achieved for validation:
100% sensitivity
All variants identified with PCR-based methods were also detected by our bioinformatics pipeline.
>99% specificity
Due to a very low false-positive rate, the varvis® CNV analysis is a very effective and reliable screening tool.
80% cost and time savings
Replace multiple expensive assays with a single comprehensive approach.
University of Magdeburg
A clincial decision support system
made for use in clinical diagnostics
The varvis® software is designed to deliver the optimum workflow for genetic testing labs and to make variant interpretation as reliable, fast and easy as possible. Cloud-native CE medical device software
Automate your NGS workflow
To really leverage all varvis® software features across your entire laboratory workflow, integration into your other software systems is key.
Build and utilize your own variant database
Systematically collect all variant data in a high-performance structured database and, at the same time, augment your data with high-quality data from all other users on our platform.
ACMG compliant classification
Interpret causative variants in concordance with the ACMG standards and store the evidence as part of your varvis® knowledgebase.
Features
Virtual panels
Quickly construct virtual panels that contain your genes of interest.
Validated CNV analysis
Increase your diagnostic yield by utilized our validated CNV analysis.
Annotations
Review all relevant variant annotation at a glance
Coverage histogram
Receive immediate QC feedback about samples/regions failing quality thresholds such as low coverage regions to optimize your lab process.
Support and software as a service
Our dedicated expert service team provides first class support regarding workflow optimization, technical support, training, documentation as well as validation following all relevant international guidelines.
No investment in IT
infrastructure
You initiate raw data upload by pushing a button. We deal with IT, processing and bioinformatics.
NGS validation as a service
Just sequence the appropriate reference samples – we take care of the rest. Regular updates are included!
Cloud-native CE medical device software
Focus on diagnostics. We are certified so you can trust the software you are using.
Overnight express
No matter how many samples or how many sequencing runs you have: our fully automated process delivers results overnight. Guaranteed.
On-boarding made simple – we get you all set up within a week!
University of Magdeburg
University of Leipzig
Synlab Zentrum für Humangenetik Mannheim
University of Göttingen
Gemeinschaftspraxis für Humangenetik & Genetische Labore Hamburg
Get in touch and see for yourself
Read more
The varvis® API facilitates integration and automation of your workflows
by Ben Liesfeld, Jan 7, 2020
We design varvis to deliver the optimum workflow for genetic testing labs. To really leverage all varvis features across your entire laboratory workflow, integration into your other software systems is key.
NGS validation as a service
by Ben Liesfeld, Nov 14, 2017
Every clinical lab is facing challenges when validating NGS assays. An automated validation process on the varvis® platform make this as simple as possible for our customers.
The new ACMG calculator in varvis®
by Yvonne Kasmann, Dec 18, 2019
varvis® now facilitates clinical variant interpretation in concordance with the ACMG standards and guidelines. The evidence for classification becomes part of your varvis knowledge base.